Pregnancy and Delivery in Penicillamine Treated Patients with Wilson′s Disease

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  • FUKUDA KAZUHIKO
    Department of Neuropsychiatry, Tohoku University School of Medicine
  • ISHII ATSUSHI
    Department of Neuropsychiatry, Tohoku University School of Medicine
  • MATSUE YOSHIHIKO
    Department of Neuropsychiatry, Tohoku University School of Medicine
  • FUNAKI KENICHI
    Department of Obstetrics and Gynecology, Tohoku University School of Medicine
  • HOSHIAI HIROSHI
    Department of Obstetrics and Gynecology, Tohoku University School of Medicine
  • MAEDA SUSUMU
    Department of Neuropsychiatry, Gunma University School of Medicine

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タイトル別名
  • Pregnancy and Delivery in Penicillamine Treated Patients with Wilson's Disease
  • Pregnancy and Delivery in Penicillamine

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Pregnancy and delivery of two patients with Wilson's disease are reported. Case 1 was a 20-year-old housewife who had been taking D-penicillamine for more than 10 years and had remained asymptomatic except an episode of dissociative reaction. She apparently survived longer than any of her three sisters who died of the same disease. She discontin-ued the use of D-penicillamine by herself when she was at the 22nd week of pregnancy. Case 2 was a 32-year-old housewife who developed an episode of mental disorder of short circuit reaction type with mild neurological symptoms and Kayser-Fleischer rings after the prolonged interval of medication since the first pregnancy and delivery. Three months after the complete recovery of neuropsychiatric symptoms she was at the 12th week of pregnancy and withheld penicillamine from herself. During the pregnancy they had not revealed any exacerbation in terms of clinical and laboratory findings. Each of them was delivered of a healthy baby. Although the pregnancy and delivery of both patients were successful, the authors recommended that they should not prolong the interval of medication to protect themselves against the onset or relapse of the illness.

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