Association of Human Leukocyte Antigen (HLA)-B5 and -BW22-J with Hepatic Cirrhosis of Apparently Unknown Etiology

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  • OHKUBO AKIYUKI
    The Third Department of Internal Medicine, Faculty of Medicine
  • OKIMOTO KYOKO
    The Third Department of Internal Medicine, Faculty of Medicine
  • IWASAKI YASUHIKO
    The Third Department of Internal Medicine, Faculty of Medicine
  • KOSAKA KINORI
    The Third Department of Internal Medicine, Faculty of Medicine
  • JUJI TAKEO
    Blood Transfusion Service, Tokyo University Hospital, University of Tokyo
  • TOHYAMA HIROSHI
    Blood Transfusion Service, Tokyo University Hospital, University of Tokyo

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  • Association of Human Leukocyte Antigen

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The majority of patients with hepatic cirrhosis in Japan do not have a history of acute hepatitis or alcoholism. Twenty-nine patients with hepatic cirrhosis which were thought as random samples from cirrhotic patients without a history of acute hepatitis or alcoholism were Human Leukocyte Antigen (HLA) typed. Association of HLA-B5 and -BW22-J with hepatic cirrhosis of apparently unknown etiology was found in p<0.003, and p<0.01, respectively (128 controls). A predisposition linked to HLA-B5 or -13W22-J related gene or genes seems to play a role in the development of hepatic cirrhosis, at least in a substantial part of patients with hepatic cirrhosis of apparently unknown etiology in Japan.

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