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- ISHIMORI AKIRA
- Department of Internal Medicine, Tohoku University School of Medicine
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- SAKURADA HIROYUKI
- Department of Internal Medicine, Tohoku University School of Medicine
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- YAMAGATA SHOICHI
- Department of Internal Medicine, Tohoku University School of Medicine
書誌事項
- タイトル別名
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- Gastrectomy and Secretory Function of the Stomach
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抄録
ISHIMORI, A., SAKURADA, H. and YAMAGATA, S. Gastrectomy and Secretory Function of the Stomach. Tohoku J. exp. Med., 1972, 107 (1), 1-13-The secretory function of the remnant of the resected stomach together with the proteolytic activity of urine was compared among various types of gastrectomy in reference to the site and the degree of resection and to atrophic gastritis in the remnant. The surgical removal of pyloric antrum was found to lower or lose the proteolytic activity of gastric juice at pH 3.5 or higher, but not of urine. Atrophic gastritis in the remnant of the resected stomach was also found to influence the acid and protease secretion of the stomach in the parallel manner, but this is less clearly seen in the proteolytic activity of urine. The step-wise dissociation between acid and protease secretion and between synthesis and secretion of protease was demonstrated as the characteristic feature of the functional disturbance of the stomach due to atrophic gastritis. Namely, the abolition of acid secretion precedes that of pepsinogen secretion and then pepsinogen continues to be synthesized and excreted into urine after the cessation of its secretion into the gastric lumen. The difference of the inborn resisting capacity among different types of secretory cells was suggested as an important contributing factor. The importance of the simultaneous measurement of the gastric and urinary proteolytic activity was stressed in order to evaluate the histologic and functional status of gastric mucosa precisely. The secreting secretory cell mass was proposed to represent reasonably the gastric secretory response obtained by the maximal stimulation.-gastric secretion; pepsin; uropepsin; gastrectomy; atrophic gastritis
収録刊行物
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- The Tohoku Journal of Experimental Medicine
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The Tohoku Journal of Experimental Medicine 107 (1), 1-13, 1972
東北ジャーナル刊行会
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詳細情報 詳細情報について
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- CRID
- 1390282679216233472
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- NII論文ID
- 130003491659
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- NII書誌ID
- AA00863920
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- COI
- 1:STN:280:CSyD2MrhtVU%3D
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- ISSN
- 13493329
- 00408727
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- NDL書誌ID
- 7672268
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- PubMed
- 4565207
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可