Laryngeal Cancer: in Relation to Oxidative Stress

DOI Web Site PubMed 参考文献43件
  • Inci Ender
    Department of Otolaryngology-Head and Neck Surgery, Cerrahpaa Medical Faculty, University of Istanbul
  • Civelek Sabiha
    Department of Biochemistry, Cerrahpaa Medical Faculty, University of Istanbul
  • Seven Arzu
    Department of Biochemistry, Cerrahpaa Medical Faculty, University of Istanbul
  • Inci Figen
    Department of Biochemistry, Cerrahpaa Medical Faculty, University of Istanbul
  • Korkut Nazim
    Department of Otolaryngology-Head and Neck Surgery, Cerrahpaa Medical Faculty, University of Istanbul
  • Burçak Gülden
    Department of Biochemistry, Cerrahpaa Medical Faculty, University of Istanbul

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説明

This study was designed to investigate the oxidative stress parameters in laryngeal cancer and cancer-free adjacent tissues. Lipid peroxidation end product and the endogenous antioxidant components-CuZn superoxide dismutase (CuZnSOD) glutathione peroxidase (GSH Px), glutathione reductase (GSSG Rd) and glutathione (GSH)-were analysed by spectrophotometric and kinetic methods. Laryngeal cancer tissue exhibited higher lipid peroxidation than cancer free adjacent tissue. CuZn SOD and GSH Px activities and GSH level were significantly higher and GSSG Rd activity significantly lower in the cancer tissue. Detection of the antioxidant status may be useful to determine the tumour resistance to therapy, to choose the correct radiotherapy-/chemotherapy and to monitor the effectiveness of the therapetic strategy.

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