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- Miura Yukio
- Department of Internal Medicine, Tohoku University School of Medicine
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説明
A simple and sensitive method for the measurement of plasma renin activity is described. The method consists of prolonged incubation (16 hours) of 2.0-3.0 ml of plasma at 37.5°C, pH 5.5, with small amounts of both ethylenediamine tetra-acetic acid and diisopropyl-fluorophosphate, purification of produced angiotensin with Dowex 50 AV-X4(H+) column chromatography, and bioassay on rat blood pressure. The recovery rate of added synthetic angiotensin II was 92.0±5.3% (s. n.). Plasma renin activity in 30 normal subjects ranged from 3.0 to 17.0 ng angiotensin equivalent per nil plasma. These values were significantly elevated in 6 cases of renovascular hypertension (20-84 nglml), in a case of interruption of the aorta (35 ng/ml), and in a case of malignant hypertension (80 ng/ml), while in 3 cases of primary aldosteronism they were suppressed to subnormal levels (2.0-2.3 ng/ml).<br> The present method is easily applicable in ordinary clinical laboratories.
収録刊行物
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- The Tohoku Journal of Experimental Medicine
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The Tohoku Journal of Experimental Medicine 98 (2), 125-134, 1969
東北ジャーナル刊行会
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詳細情報 詳細情報について
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- CRID
- 1390282679216876672
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- NII論文ID
- 130003497975
- 40018682829
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- NII書誌ID
- AA00863920
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- COI
- 1:CAS:528:DyaE3cXpsFKi
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- ISSN
- 13493329
- 00408727
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- NDL書誌ID
- 8507869
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- PubMed
- 4309405
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可