Virus in Human Cancer and Leukemia

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  • AWANO ISAMU
    The First Department of Internal Medicine, Fukushima Medical College
  • SANBE MITSUYOSHI
    The First Department of Internal Medicine, Fukushima Medical College
  • YOSHIDA HIROSHI
    The First Department of Internal Medicine, Fukushima Medical College

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The electron microscopic studies were carried out in order to detect tumor virus from the biopsy materials of cancer- and leukemic-tissues in man. Metastatic cancer tissues of lymph gland obtained from the patients with stomach or lung cancer, and leukemic tissues of lymph gland and spleen from a patient with acute myeloid leukemia were also used for the studies. Virus-like particles about 100-150mμ in size, each of which has a core about 60-70mμ in size, were found in the cytoplasm or cytoplasmic vacuoles of the metastatic lymph gland tissue cells from the patients with stomach or lung cancer. Mature C-type virus-like particles about 100mμ in size, each of which has a core about 60mμ in size, were found in the cytoplasm of leukemic cells of spleen and lymph gland tissues from a patient with acute myeloid leukemia. These virus-like particles may be an inducer in the process of carcino- and leukemogenesis in man as in animals. A variety of nuclear bodies and the osmiophilic nuclear particles resembling the core of cytoplasmic virus-like particles in size were found in the nucleus of cancer cells from the patients with stomach or lung cancer. These osmiophilic nuclear particles might be formed in the nuclear bodies, removed to the nuclear membrane, then extruded through the nuclear membrane into the cytoplasm and the outer shell of the cytoplasmic virus-like particles might be formed in the cytoplasm. In the extra-cellular space of cancer cells, doughnut-shaped small particles about 60-80mμ in size were demonstrated together with the virus-like particles, one of which seems to be in a process of budding.

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