Pulmonary Alveolar Surfactant in Irradiated Lung of Rat

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  • OIKAWA MASARU
    Department of Radiology, Iwate Medical University, School of Medicine

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Abstract

Male rats of Wistar strain, weighing 250-350g were given 5, 000 R and 7, 000 R, respectively, to their right lungs. Samples were taken from non-irradiated areas (left lung) and atelectatic areas of irradiated lung. Histologic sections were made and alveolar bubble stability was estimated. The data were compared with those of control rats. The results indicate that following irradiation the atelectatic areas show decreased alveolar bubble stability ratios, suggesting the diminution of alveolar lining surface-active material.

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