Analysis of Diastolic Pressure-Volume Relation of the Canine Left Ventricle: Half-Inflation Pressure as an Index of Left Ventricular Compliance
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- NAKAMURA TOSHIO
- Department of Internal Medicine, Tohoku University School of Medicine
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- NAKAJIMA TOSHIYUKI
- Department of Internal Medicine, Tohoku University School of Medicine
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- TAKISHIMA TAMOTSU
- Department of Internal Medicine, Tohoku University School of Medicine
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- SUZUKI NORIO
- College of Medical Sciences,* Tohoku University
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- ARAI SHIGERU
- Department of Pathology, Tohoku University School of Medicine
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- SUWA NORIO
- Department of Pathology, Tohoku University School of Medicine
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説明
A sensitive index was proposed for the determination of left ventricular compliance. In the isolated potassium-arrested canine left ventricle, the pressure-volume (P-V) relationship was expressed as ΔV =a-be-cp throughout the range of filling pressure from 0 to 40cmH2O, where ΔV and P were the actual volume change and intraventricular pressure, and a, b and c were constants. Then, half-inflation pressure (h) was calculated from h=[ln (2b/a)]/c. Left ventricular weight (LVW), intraven-tricular volume (LVV), ventricular external radius (r0) and internal radius (ri) were obtained from the measurements on the left ventricle, fixed at a filling pressure of 10cmH2O. Then, LVVp=h, ro and ri at h were calculated. In the normal canine hearts, h was well correlated to LVW/LVVp=h and [(r0- ri)/ri]p=h. On the other hand, h/LVW/LVVp=h and h/[(r0-ri)/ri]p=h were constant and independent of LVW within a range of 40 to 150g. These ratios rose markedly in the state of rigor mortis. From these results, it was concluded that h/LVW/LVVp=h and h/[(r0-ri)/ri]p=h depended on the left ventricular wall stiffness. And h was influenced by changes in LVW/LVVp=h and [(r0-ri)/ri]p=h in the absence of changes in intrinsic muscle stiffness.
収録刊行物
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- The Tohoku Journal of Experimental Medicine
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The Tohoku Journal of Experimental Medicine 117 (4), 311-321, 1975
東北ジャーナル刊行会