Determination of prostaglandins and the effect of indomethacin on rat gastric mucosa.
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- KOBAYASHI KENZO
- The Third Department of Internal Medicine, Osaka City Unversity Medical School
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- ARAKAWA TETSUO
- The Third Department of Internal Medicine, Osaka City Unversity Medical School
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- NAKAMURA HAJIME
- The Third Department of Internal Medicine, Osaka City Unversity Medical School
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- CHONO SHINJI
- The Third Department of Internal Medicine, Osaka City Unversity Medical School
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- YAMADA HIROAKI
- The Third Department of Internal Medicine, Osaka City Unversity Medical School
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- YAMAMOTO SUKEO
- The Third Department of Internal Medicine, Osaka City Unversity Medical School
Bibliographic Information
- Other Title
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- Determination of Prostaglandins and the
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Abstract
KOBAYASHI, K., ARAXAWA, T., NAKAMURA, H., CHONO, S., YAMADA, H. and YAMAMOTO, S. Determination of Prostaglandins and the Effect of Indomethacin on Rat Gastric Mucosa. Tohoku J. exp. Med., 1981, 135 (4), 371-378-Prostaglandins protect the gastrointestinal mucosa against various ulcerogens. There are only a few reports about endogenous prostaglandins in the gastric mucosa. We present a method for determining mucosal prostaglandins and an investigation on the effect of indomethacin on prostaglandin E2 levels in the rat gastric mucosa. The levels of prostaglandins B, E1, E2, and F were higher in the antral mucosa (311±123, 632±147, 2099±455, and 415±115 ng/g, respectively) than in the fundic mucosa (33±2, 202±38, 914±229, and 138±22 ng/g, respectively). In both mucosal tissues, the prostaglandin E, level was the highest and it was markedly reduced with indomethacin in a dose-related manner. The difference in the mucosal levels of prostaglandins suggests that in rats, mucosal damage occurs mainly in the fundus. The observed marked reduction of mucosal prostaglandin E2 following the administration of indomethacin may aid in elucidating the pathogenesis of gastric mucosal lesions induced by these types of agents. mucosal prostaglandin E2; indomethacin; cytoprotection; gastric mucosal lesions; radioimmunoassay
Journal
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- The Tohoku Journal of Experimental Medicine
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The Tohoku Journal of Experimental Medicine 135 (4), 371-378, 1981
Tohoku University Medical Press
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Details 詳細情報について
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- CRID
- 1390282679217177088
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- NII Article ID
- 130003492895
- 40005306853
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- NII Book ID
- AA00863920
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- COI
- 1:CAS:528:DyaL38XpvVCmtQ%3D%3D
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- ISSN
- 13493329
- 00408727
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- NDL BIB ID
- 2477253
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- PubMed
- 7336427
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed