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- HANEW KUNIHIKO
- The Second Department of Internal Medicine, Tohoku University School of Medicine
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- SASAKI ATSUSHI
- The Second Department of Internal Medicine, Tohoku University School of Medicine
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- YOSHINAGA KAORU
- The Second Department of Internal Medicine, Tohoku University School of Medicine
書誌事項
- タイトル別名
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- Evidence for Endogenous Dopaminergic Co
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説明
HANEW, K., SASAKI, A. and YOSHINAGA, K. Evidence for Endogenous Dopaminergic Control of GH Release in Man. Tohoku J. exp. Med., 1981, 135 (1), 103-108 - In order to determine whether or not there is a tonic dopamine (DA) control of GH release, the effect of an anti-dopaminergic agent, sulpiride, on GH secretion was studied in 12 normal subjects. After the administration of sulpiride, serum concentrations of sulpiride reached a peak value (1.93±0.1 μg/ml, mean±S.E.M., n=6) at 15min and then showed a gradual decrease. Concomitantly, mean plasma prolactin (PRL) showed a rapid elevation, with a peak value of 161.9±11.5ng/ml at 30min, followed by a gradual decrease. Even at 180min after sulpiride injection, the plasma PRL was still 9 times higher than the initial level (p<0.005). Within 90min after the injection, 12 subjects showed a minimal but significant decrease in GH (from 0.78±0.17 to 0.32±0.03ng/ml, p<0.02). After another 90min, the plasma GH level increased and the mean peak value (8.1±2.7ng/ml) at 180min was significantly higher than the initial value (p<0.02). From these observations, it was suggested that sulpiride inhibited the endogenous DA activity over 180min, and that the GH decrease within 90min was due to a suppression of endogenous DA activity. Factors other than DA, however, might be considered for the GH increase after 90min.
収録刊行物
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- The Tohoku Journal of Experimental Medicine
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The Tohoku Journal of Experimental Medicine 135 (1), 103-108, 1981
東北ジャーナル刊行会
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詳細情報 詳細情報について
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- CRID
- 1390282679217486336
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- NII論文ID
- 130003492858
- 40005306817
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- NII書誌ID
- AA00863920
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- COI
- 1:CAS:528:DyaL3MXlsVyitrs%3D
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- ISSN
- 13493329
- 00408727
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- NDL書誌ID
- 2358927
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- PubMed
- 7324044
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可