Effects of nifedipine on the renal vascular responses and blood pressure responses to norepinephrine and angiotensin II in the anesthetized rabbit.

DOI Web Site PubMed 1 Citations Open Access
  • ITO SADAYOSHI
    Second Department of Internal Medicine, Tohoku University School of Medicine
  • SEINO MASAHIDE
    Second Department of Internal Medicine, Tohoku University School of Medicine
  • YASUJIMA MINORU
    Second Department of Internal Medicine, Tohoku University School of Medicine
  • ABE KEISHI
    Second Department of Internal Medicine, Tohoku University School of Medicine
  • YOSHINAGA KAORU
    Second Department of Internal Medicine, Tohoku University School of Medicine

Search this article

Description

ITO, S., SEINO, M., YASUJIMA, M., ABE, K. and YOSHINAGA, K. Effects of Nifedipine on the Renal Vascular Responses and Blood Pressure Responses to Norepinephrine and Angiotensin II in the Anesthetized Rabbit. Tohoku J. exp. Med., 1983, 140 (1), 53-58-Effects of a Ca-antagonist, nifedipine, on renal vascular responses and systemic pressor responses to angiotensin II and norepinephrine were studied in anesthetized rabbits. The changes of renal blood flow were estimated by an electromagnetic flowmeter. After the intravenous administration of nifedipine (50μg/kg), mean blood pressure decreased from 116±3.1mmHg to 102±3.4mmHg (p<0.001). Renal vascular responses to angiotensin II were attenuated significantly after the administration of nifedipine, but not changed to norepinephrine. Pressor responses to angiotensin II at a low dose were significantly diminished after the administration of nifedipine (p<0.05), whereas it had no effect at higher doses. Nifedipine tended to suppress the increase in arterial pressure induced by norepinephrine, but the changes were not statistically significant. These results suggest that calcium influx in the vascular smooth muscle cells is not likely to be a common pathway in the vasoconstrictor reaction to angiotensin II and norepinephrine in anesthetized rabbit.

Journal

Citations (1)*help

See more

Keywords

Details 詳細情報について

Report a problem

Back to top