Treatment of Adult Acute Non-lymphoblastic Leukemia Using Intermittent Combination Chemotherapy with Daunomycin, Cytosine Arabinoside, 6-Mercaptopurine and Prednisolone-DCMP Two Step Therapy

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  • UZUKA YOSHIRO
    The Third Department of Internal Medicine, Tohoku University School of Medicine
  • LIONG SING KHIONG
    The Third Department of Internal Medicine, Tohoku University School of Medicine
  • YAMAGATA SHOICHI
    The Third Department of Internal Medicine, Tohoku University School of Medicine

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  • Treatment of adult acute non lymphoblas

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A regime of treatment of acute non-lymphoblastic leukemia in adult, employing DMCP protocol, especially two step method consisting of daunorubicin, cytosine arabinoside, 6-mercaptopurine and prednisolone is described. Out of 32 adult patients with ANLL treated with DCMP regime 26 (81.3%) achieved complete remission. The median durations of complete remission and survival were 53 weeks and 54 weeks, respectively. The longest duration of complete remission was more than 220 weeks, and 3 cases are still maintaining initial complete remission more than 3 years.

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