Influences of Ethynodiol Diacetate (SC 11800) on Estrous Cycle and Pituitary Gonadotropin

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  • SUZUKI MASAKUNI
    Department of Obstetrics and Gynecology, Tohoku University School of Medicine
  • HIROI MASAHIKO
    Department of Obstetrics and Gynecology, Tohoku University School of Medicine
  • TAKAHASHI KATSUYUKI
    Department of Obstetrics and Gynecology, Tohoku University School of Medicine

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In order to know the mode of action of ethynodiol diacetate (SC 11800) in comparison with actions of progesterone, estradiol benzoate and testosterone propionate, several doses of SC 11800 were administered to mature female rats, and the estrous cycle and gonadotropin content in the hypophysis were observed. The pituitary gonadotropin changed periodically during the normal cycle, and FSH showed each maximal level in the proestrus, while prolactin showed its maximum level in the estrus. Administration of SC 11800 in a dose of 0.01mg/kg caused no changes in the estrus cycle, but the increased dose of 0.5mg/kg or 1.0mg/kg caused a continuous diestrus and marked increase of pituitary LH. In cases of administration of several steroids, progesterone and testosterone caused a continuous diestrus, while estradiol caused a continuous estrus. The contents of pituitary gonadotropin after the administration of what were greatly different from those after SC 11800. Accordingly, SC 11800 was assumed to have a mode of action different from the steroids.

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