Effect of Dibutyryl Cyclic-AMP on Cardiac Output and Myocardial Contractility in Dogs
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- OKUAKI AKIRA
- Department of Anesthesiology, Fukushima Medical College
書誌事項
- タイトル別名
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- Effects of dibutyryl cyclic-AMP on cardiac output and myocardial contractility in dogs.
- Effect of Dibutyryl Cyclic AMP on Cardi
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抄録
Dibutyryl cyclic-AMP was administered to a group of anesthetized dogs at the doses of 5, 10, 20 and 40 mg/kg, and changes in stroke volume, cardiac output and myocardial contractility were observed. Also, effects of this substance on contractile performance of isolated cardiac muscle were investigated in another group of dogs. Results were as follows: 1) Dibutyryl cyclic-AMP increased heart rate, stroke volume and cardiac output in a dose-related manner in the range from 5 to 40 mg/kg. 2) As indices of myocardial contractility, Vmax and maximum dF/dt were examined. These also showed a dose-dependent increase in response to dibutyryl cyclic-AMP. In isolated dog hearts, dibutyryl cyclic-AMP raised the maximum velocity of shortening (V'max) dose-dependently. 3) Total peripheral resistance declined in a dose-related way. On the other hand, mean arterial pressure and CVP dropped slightly without showing dose-dependence-These results show that dibutyryl cyclic-AMP produces positive inotropic and chronotropic effects and cause dilatation of the peripheral vessels in dose-dependent manners.
収録刊行物
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- The Tohoku Journal of Experimental Medicine
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The Tohoku Journal of Experimental Medicine 123 (2), 139-145, 1977
東北ジャーナル刊行会
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キーワード
詳細情報 詳細情報について
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- CRID
- 1390282679217959424
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- NII論文ID
- 130003492367
- 40005305998
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- NII書誌ID
- AA00863920
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- COI
- 1:CAS:528:DyaE1cXmvFOlsQ%3D%3D
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- ISSN
- 13493329
- 00408727
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- NDL書誌ID
- 1913630
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- PubMed
- 201047
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可