Massive Intramedullary Globules in IgA Monoclonal Gammopathy Associated with Gastric Carcinoma
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- KANOH TADASHI
- The First Division, Department of Internal Medicine
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- UCHINO HARUTO
- The First Division, Department of Internal Medicine
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- KUSAKA MOTOO
- the Department of Internal Medicine, Horikawa Hospital
書誌事項
- タイトル別名
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- Massive Intramedullary Globules in IgA
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抄録
The bone marrow of a patient with IgA monoclonal gammopathy associated with gastric carcinoma was massively infiltrated with extracellular globules of varying sizes from 2 to 110μm. These exposed globules were not found in the metastatic lesions heavily infiltrated with plasma cells, but were exclusively confined to the bone marrow. They were indistinguish-able from Russell bodies and composed of monoclonal immunoglobulin (IgA, λ). Of interest is the fact that, despite a small number of plasma cells, there was an intramedullary extensive infiltration of exposed globules. The following conditions may be related to these changes. (1) The globules were not removed rapidly by effectual phagocytosis. (2) The environment of the bone marrow may be favor-able for their remaining. In our case, however, the possibility that the plasma cells around the tumor were not of the same clonal origin as the marrow plasma cells cannot be ruled out. (3) The marrow plasma cells may produce immunoglobulin more vigorously, whereas their survival time be shorter than usual. As a result, these exposed globules released on the death of the cells accumulated massively in the bone marrow.
収録刊行物
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- The Tohoku Journal of Experimental Medicine
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The Tohoku Journal of Experimental Medicine 123 (4), 343-349, 1977
東北ジャーナル刊行会
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詳細情報 詳細情報について
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- CRID
- 1390282679218013184
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- NII論文ID
- 130003492381
- 40005306029
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- NII書誌ID
- AA00863920
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- COI
- 1:STN:280:DyaE1c7hvVektQ%3D%3D
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- ISSN
- 13493329
- 00408727
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- NDL書誌ID
- 1916946
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- PubMed
- 204078
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可