Effects of Imidazole and Phentolamine on the Relaxant Responses of Guinea-pig Taenia Coli to Transmural Stimulation and to Adenosine Triphosphate

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  • RIKIMARU AKIRA
    Department of Applied Physiology, Tohoku University School of Medicine
  • FUKUSHI YASUE
    Department of Applied Physiology, Tohoku University School of Medicine
  • SUZUKI TAIZO
    Department of Applied Physiology, Tohoku University School of Medicine

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The effects of imidazole and phentolamine on the relaxant responses of the isolated guinea-pig taenia coli to transrural stimulation (1 msec, 5 pulses/sec) and to ATP (10-6-10-5g/ml) were studied. The relaxation produced by ATP was entirely abolished by imidazole (3.5×10-3g/ml) or phentolamine (5×10-5g/ml), though the relaxation due to transmural stimulation remained unimpaired. These results are rather controversial to the concept that the transmitter substance of the non-adrenergic inhibitory nerves in the gastrointestinal tract is ATP.

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