Helper and suppressor T-cells regulating killer cells of EB virus infected cells.
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- YOSHIMURA NAOKO
- Department of Pediatrics, School of Medicine, Tokyo Medical and Dental University
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- YATA JUNICHI
- Department of Pediatrics, School of Medicine, Tokyo Medical and Dental University
Bibliographic Information
- Other Title
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- Helper and Suppressor T Cells Regulatin
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Abstract
YOSHIMURA, N. and YATA, J. Helper and Suppressor T-Cells Regulating Killer Cells of EB Virus Infected Cells. Tohoku J. exp. Med., 1983, 140 (4), 353-362 -Using an in-vitro human lymphocyte system, a study was performed to determine whether helper T-cells and suppressor T-cells control the generation of killer cells against autologous B-cells transformed by Epstein-Barr (EB) virus. When T-cells were treated with mitomycin C and reacted in the presence of macrophages with target cells bearing HLA-DR, helper T-cells were induced but suppressor T-cells were not. In contrast, when T-cells were reacted in the absence of macrophages to target cells lacking HLA-DR, suppressor T-cells but not helper T-cells were induced. The culture supernatant of the T-cells which showed suppressor activity also suppressed the generation of killer cells. The thus-induced suppressor T-cells also suppressed the HLA incompatible allogeneic killer cells which were directed against autologous B-cells transformed by EB virus and also autologous killer cells directed against allogeneic target cells. These observations indicated that there is no HLA restriction between the suppressor T-cells and the killer cells and the suppression is antigen nonspecific.
Journal
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- The Tohoku Journal of Experimental Medicine
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The Tohoku Journal of Experimental Medicine 140 (4), 353-362, 1983
Tohoku University Medical Press
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Details 詳細情報について
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- CRID
- 1390282679218076288
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- NII Article ID
- 130003493172
- 40005307100
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- NII Book ID
- AA00863920
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- COI
- 1:STN:280:BiuD2crnvFE%3D
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- ISSN
- 13493329
- 00408727
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- NDL BIB ID
- 2637123
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- PubMed
- 6314594
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed