Expression of Nuclear Factor-Kappa B and Placental Apoptosis in Pregnancies Complicated with Intrauterine Growth Restriction and Preeclampsia: An Immunohistochemical Study
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- Aban Meral
- Department of Obstetrics and Gynecology, University of Mersin
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- Cinel Leyla
- Department of Pathology, University of Mersin
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- Arslan Murat
- Department of Obstetrics and Gynecology, University of Mersin
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- Dilek Umut
- Department of Obstetrics and Gynecology, University of Mersin
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- Kaplanoglu Mustafa
- Department of Obstetrics and Gynecology, University of Mersin
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- Arpaci Rabia
- Department of Pathology, University of Mersin
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- Dilek Saffet
- Department of Obstetrics and Gynecology, University of Mersin
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説明
Preeclampsia affects 7-10% of all pregnancies, and is a major cause of maternal and fetal morbidity and mortality. Although enhanced apoptosis is well known in placentas with preeclampsia, the role of transcription factor nuclear factor-kappa B (NF-κB) in the process is still being debated. In this work, we investigate the relationship between NF-κB expression and trophoblastic cell apoptosis in pregnancies complicated with preeclampsia or intrauterine growth restriction (IUGR) by immunohistochemical analysis of NF-κB and three apoptosis related markers: bcl-2, caspase-3, and M30 CytoDeath antibody that identifies early apoptotic changes in the cytoskeleton related to action of caspase. The study was conducted on placental samples from 19 preeclamptic, 5 IUGR-complicated and 10 normal pregnant women. The three conclusions from the statistical analysis of the data are obtained; (i) Significantly higher expression of NF-κB in IUGR-complicated (p = 0.003) and preeclamptic placentas (p = 0.004) than the control placentas, (ii) significantly higher M30 index and caspase 3 expression in IUGR and preeclampsia placentas (p = 0.003), and (iii) decreased expression of bcl-2 in IUGR and preeclampsia placentas (p = 0.001). Based on these observations, we suggest that increased trophoblastic apoptosis is at least partially induced by NF-κB and reduced bcl-2 expression.
収録刊行物
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- The Tohoku Journal of Experimental Medicine
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The Tohoku Journal of Experimental Medicine 204 (3), 195-202, 2004
東北ジャーナル刊行会
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詳細情報 詳細情報について
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- CRID
- 1390282679218673280
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- NII論文ID
- 130004459353
- 10013719341
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- NII書誌ID
- AA00863920
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- ISSN
- 13493329
- 00408727
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- PubMed
- 15502418
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- 本文言語コード
- en
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- 資料種別
- journal article
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- データソース種別
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- JaLC
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可