Studies on the Cells Responsible for the Delayed Type of Hypersensitivity with Special Reference to Lymphocytes

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The purpose of this paper is to determine what kind of cell is involved in antibody production in the delayed type of hypersensitivity and to clarify the mechanism by which the cells participate in the process. Attempts to solve these problems have been made in four ways: 1) Passive transfer of delayed type of hypersensitivity with lymphocytes, neutrophils and peritoneal exudate cells (living and disrupted), 2) tests for neutralization of tuberculin by lymphocytes (living and disrupted), 3) attempted breakdown of acquired and native im-munological tolerance to tuberculin with lymphocytes (living and disrupted), and 4) development of tuberculin hypersensitivity in thymectomized rabbits.<br> All results of these experiments suggest that lymphocytes are responsible for the exhibition of hypersensitivity.<br> Reviewing my own and other author's data, a new conception is presented which copes with the mechanism of the passive transfer of hypersensitivity as well as with the breakdown of immunological tolerance by living or disrupted lymphocytes.<br> The core of the conception is that the recipient's own immunologically competent cells are also involved in the development of hypersensitivity, receiving some information from living lymphocytes or lymphocyte fragments transferred.

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