Study on the distribution of 131I labeled toxohormone

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  • Study on the Distribution of <sup>131</sup>I Labeled Toxohormone

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The distribution rate of sodium iodide (Na131I) and toxohormone labeled with Na131I in rats under various experimental conditions was described.<br> Toxohormone extracted from the cancer tissue of the stomach removed by surgical operation exhibited a remarkable inhibitory effect on liver catalase.<br> Compared with the distribution of Na131I in the liver and spleen of the normal rats, that of Na131I labeled toxohormone in the above organs was found to be characteristically decreased. It was also decreased in the liver of splenectomized rats. The distribution of Na131I was reduced in the liver and spleen of rats, which had been treated with toxohormone for successive two days. It was also decreased in the above organs of rats with moderate liver impairment.<br> The function of the reticuloendothelial system in the liver and spleen of the tumor bearing organisms was regarded to be important in the inactivation of toxohormone released from tumor tissue.<br> The distribution rate of labeled toxohormone in the alimentary canal, especially in the stomach, was found to be increased after intraperitoneal administration of the substance. The results were interpreted in association with the excretion of Na131I labeled toxohormone from the alimentary canal.

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