The Influence of Hormonal Disturbances on the Survival of Liver-damaged Animals

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  • Kulcsár A.
    The First Medical Clinic, and Department of Pharmacology, Medical University
  • Kulcsár-Gergely J.
    The First Medical Clinic, and Department of Pharmacology, Medical University

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In the present experiments we have investigated the effect of ovariectomy and/or thyroidectomy upon the death rate in rats poisoned with carbon tetrachloride. It was found that the death rate of the ovariectomized rats was lower than that in non-spayed animals. Thyroidectomy also produced a significant decrease in the death rate of the carbon tetrachloride-treated animals. Almost the same results were obtained by thyroidectomy plus ovariectomy.<br> These findings may be explained by assuming that the extirpation of the ovaries and/or the thyroid lessens overburden of the intoxicated liver.

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