The Decrepitude of the Rat Brain with Special Reference to Changes in Nucleic Acid

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  • Yajima Akira
    Department of Obstetrics and Gynecology, Tohoku University School of Medicine

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The cerebrum, cerebellum, diencephalon and brain stem of female rats were studied for their contents of nucleic acid bases, and the values obtained were compared between maturity and decrepitude.<br> There was recognized no difference in contents of the DNA bases, i.e., guanine (G), adenine (A), cytosine (C) and thymine (T), among the portions of the brain as well as between maturity and decrepitude. Contents of RNA bases guanine, adenine, cytosine and uracil (U) did not show any variation according to portions of the brain both in mature and decrepit rats; however, in the latter, as compared with the former, the four portions of the brain all gave a lower value of guanine and a higher level of uracil; thus there was noted a declining tendency of (G+C) /(A+U).<br> In comparison of the nucleic acid fractions of the diencephalon between mature and decrepit rats, the RNA/DNA ratio was reduced in the latter as compared with that in the former. s-RNA/DNA, r1-RNA/DNA and r2-RNA/DNA were found lower in decrepit than those in mature rats. Especially r2-RNA/DNA, that is the ratio of the high molecular portion of ribosome RNA to DNA, was markedly reduced.

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