Autoimmune Phenomenon in Eczema Seborrhoeicum

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  • Hashimoto Isao
    Department of Dermatology, Hirosaki University School of Medicine

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The serum and the involved skin tissue of patients with eczema seborrhoeicum were examined for the antibodies against the scale infusion. Ouchterlony's diffusion-in-gel test was positive in 5 (38%) of 13 cases. In passive cutaneous anaphylaxis, a kind of delayed reaction was observed 24 hours after the chal-lenge. This reaction was positive in 8 (62%) of 13 cases. The specific method of fluorescent antibody demonstrated the specific fluorescence in the granular and basal layers of the involved skin tissue in 4 (57%) of 7 cases. In one of them the fluorescence was weakened after triamcinolone therapy. The active principles responsible for the above positive reactions were called precipitating antibody, passive cutaneous anaphylaxis antibody and cellular antibody, respectively.<br> From an analysis of the relationship between the above three kinds of antibodies and the clinical pictures, it was inferred that in some cases of eczema seborrhoeicum a kind of contact allergy developed to the autologous seborrheic scales. This autoimmune phenomenon may play an important role in generalization and eezematization, or in intractability of the lesions of eczema seborrhoeicum.

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