Metallophil Cells in Subcutaneous Nodes of Yoshida Sarcoma in Rats

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  • Katsura Sukemoto
    The Second Department of Pathology, School of Medicine, Iwate Medical University
  • Satodate Ryoichi
    The Second Department of Pathology, School of Medicine, Iwate Medical University

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Description

he metallophil cells of round, branching and foamy types were found in the subcutaneous nodes of Yoshida sarcoma in rats of Wistar strain by the ammoniacal silver impregnation method. The metallophil cells showed positive results for vital staining, iron reaction and various histocheniical reactions. In electron microscopy, silver granules were deposited selectively in the matrix of the cytoplasm. These findings led to the conclusion that the metallophil cells belonged to the reticuloendothelial system.<br> The branching and the foamy metallophil cells were found chiefly in the tumor, and the round metallophil ones in the surrounding tissue.<br> At the 12th hour of the transplantation, the number of metallophil cells rapidly increased, but it decreased at the 24th hour. The cells then increased again and reached a level which exceeded the initial increase after the transplanta-tion. The second high level was maintained until the 14th day. Thereafter, the number of the cells returned to a low level. The changes of the metallophil cells were very similar in both the tumor and the surrounding tissue. The second rise and decline of metallophil cells seemed to be related to the develop-ment of the tumor.

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