Tryptophan Load and Uptake of Tryptophan by Leukocytes in Hartnup Disease

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  • Tada Keiya
    Department of Pediatrics, Faculty of Medicine, Tohoku University
  • Morikawa Toshio
    Department of Pediatrics, Faculty of Medicine, Tohoku University
  • Arakawa Tsuneo
    Department of Pediatrics, Faculty of Medicine, Tohoku University

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Two patients with Hartnup disease were studied for tryptophan loading test. The increase in kynurenine and N-methylnicotinamide following the tryptophan loading was less remarkable in the Hartnup patients than in controls. On the other hand, the Hartnup patients revealed a striking elevation of indoleacetic acid and indican following the loading as compared with those in controls. Plasma levels of tryptophan following the loading indicated a lower peak in the Hartnup patients than in controls. These results suggest malabsorption of tryptophan in the intestine.<br> The in ritro studies on uptake of tryptophan by leukocytes failed to demonstrate a specific defect in transport of tryptopha.n in a Hartnup patient.

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