Histochemical Studies on the Diencephalon of Senescent Rats

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  • Kaneta Naotake
    Department of Obstetrics and Gynecology, Tohoku University School of Medicine

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Histochemical investigations were made upon activities of succinic dehydro-genase, lactic dehydrogenase, nicotinamide adenine dinucleotide diaphorase, cytochrome oxidase and glucose-6-phosphate dehydrogenase, and contents of copper and of nucleic acids in the diencephalon of rats in reference to aging.<br> 1) In the diencephalon of senescent rats, a slight decrease of activity of glucose-6-phosphate dehydrogenase and a slight increase in the activities of both succinic dehydrogenase and cytochrome oxidase in the supraoptic and paraventricular nuclei were found.<br> 2) A deposition of copper was increased with aging in the stratum periventriculare hypothalami, fimbria hippocampi and habenular nucleus.<br> 3) A decrease of cytoplasmic RNA content of the diencephalon and an increase of RNA in the supraoptic nucleus as well as paraventricular nucleus were found with advancing age.

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