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- Tada Keiya
- Department of Pediatrics Faculty of Medicine, Tohoku Univeristy
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- Yokoyama Yoshimasa
- Department of Pediatrics Faculty of Medicine, Tohoku Univeristy
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- Nakagawa Hiroshi
- Department of Pediatrics Faculty of Medicine, Tohoku Univeristy
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- Yoshida Toshio
- Department of Pediatrics Faculty of Medicine, Tohoku Univeristy
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- Arakawa Tsuneo
- Department of Pediatrics Faculty of Medicine, Tohoku Univeristy
書誌事項
- タイトル別名
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- Vitamin B<sub>6</sub> Dependent Xanthurenic Aciduria
この論文をさがす
抄録
Two children (siblings) with mental retardation revealed an excessive output of xanthurenic acid, kynurenic acid, 3-hydroxykynurenine and kvnurenine in urine following tryptophan loading. The disturbance was normalized tem-porarily by treatment with large doses of vitamin B6. The levels of pyridoxal phosphate in sera from both the patients were found to be within normal limits.<br> It was found that the activity of kynureninase in the liver of the patient was markedly reduced without addition of pyridoxal phosphate but the activity was restored to a considerable extent by the addition of an excess of pyridoxal phosphate.<br> These findings suggest that the basic defect in the patients is an inability of apoenzyme (kynureninase) to combine normally with the coenzyme (pyridoxal phosphate). The present studies, in combination with the work of Frimpter et al. on cystathionuria, may give us biochemical understanding for so-called vitamin B6 dependency.
収録刊行物
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- The Tohoku Journal of Experimental Medicine
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The Tohoku Journal of Experimental Medicine 93 (2), 115-124, 1967
東北ジャーナル刊行会
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詳細情報 詳細情報について
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- CRID
- 1390282679219405440
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- NII論文ID
- 130003497787
- 40018682612
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- NII書誌ID
- AA00863920
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- COI
- 1:CAS:528:DyaF1cXivVSjsA%3D%3D
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- ISSN
- 13493329
- 00408727
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- NDL書誌ID
- 8507652
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- PubMed
- 5586569
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可