The Analysis of the Sweat Response to Tetramethyl-ammonium in Human Skin

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Abstract

By using the band method and four blocking agents, it was demonstrated that the sweat response to intradermal injections of tetramethylammonium (TMA) in human skin consists of two components: at a concentration of 10-5, TMA elicits the sweat response mainly by acting on the sweat glands; and 5×10-4 or higher concentrations, it produces an axon reflex sweating in addition by acting on the receptors responsible for the axon reflex. The optimum concentration for the axon reflex was found to be 10-4.<br> The initiation of the axon reflex by TMA was inhibited by procaine, hexamethonium and tetraethylammonium (TEA) possibly at the site of the receptors responsible. The sweat response elicited by the direct action of TMA was scarcely interfered with by these agents in the concentrations sufficient to inhibit completely the axon reflex. Atropine in relatively low concentrations suppressed the sweating produced by the direct action of TMA, whereas it blocked the axon reflex response by acting on the receptors at relatively high concentrations.

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