Approach to novel functional foods for stress control: 4. Regulation of serotonin transporter by food factors

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  • Ito Mikiko
    Institute of Health Biosciences, The University of Tokushima Graduate School Project team of the 21st century COE program “Human Nutritional Science on Stress Control”, Institute of Health Biosciences, The University of Tokushima Graduate School
  • Haito Sakiko
    Institute of Health Biosciences, The University of Tokushima Graduate School
  • Furumoto Mari
    Institute of Health Biosciences, The University of Tokushima Graduate School
  • Kawai Yoshichika
    Institute of Health Biosciences, The University of Tokushima Graduate School Project team of the 21st century COE program “Human Nutritional Science on Stress Control”, Institute of Health Biosciences, The University of Tokushima Graduate School
  • Terao Junji
    Institute of Health Biosciences, The University of Tokushima Graduate School Project team of the 21st century COE program “Human Nutritional Science on Stress Control”, Institute of Health Biosciences, The University of Tokushima Graduate School
  • Miyamoto Ken-ichi
    Institute of Health Biosciences, The University of Tokushima Graduate School Project team of the 21st century COE program “Human Nutritional Science on Stress Control”, Institute of Health Biosciences, The University of Tokushima Graduate School

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Serotonin transporters (SERTs) are pre-synaptic proteins specialized for the clearance of serotonin following vesicular release at central nervous system (CNS) and enteric nervous system synapses. SERTs are high affinity targets in vivo for antidepressants such as serotonin selective reuptake inhibitors (SSRIs). These include ‘medical’ psychopharmacological agents such as analgesics and antihistamines, a plant extract called St John’s Wort (Hypericum). Osteoclasts are the primary cells responsible for bone resorption. They arise by the differentiation of osteoclast precursors of the monocyte/macrophage lineage. The expression of SERTs was increased in RANKL-induced osteoclast-like cells. Using RANKL stimulation of RAW264.7 cells as a model system for osteoclast differentiation, we studied the direct effects of food factor on serotonin uptake. The SSRIs (fluoxetine and fluvoxamine) inhibited markedly (-95%) in serotonin transport in differentiated osteoclast cells. The major components of St. John’s Wort, hyperforin and hypericine were significantly decreased in serotonin transport activity. Thus, a new in vitro model using RANKL-induced osteoclast-like cells may be useful to analyze the regulation of SERT by food factors and SSRIs. J. Med. Invest. 52 Suppl.: 245-248, November, 2005

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