Effects of cardiotrophin-1 on hemodynamics and cardiomyocyte apoptosis in rats with acute myocardial infarction
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- Yin Ruixing
- Department of Cardiology, Institute of Cardiovascular Diseases, Guangxi Medical University
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- Yang Dezhai
- Department of Cardiology, Institute of Cardiovascular Diseases, Guangxi Medical University
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- Li Jiaquan
- Department of Cardiology, Institute of Cardiovascular Diseases, Guangxi Medical University
書誌事項
- 公開日
- 2004
- 資源種別
- journal article
- DOI
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- 10.2152/jmi.51.29
- 公開者
- 国立大学法人 徳島大学医学部
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説明
The effects of cardiotrophin-1 on hemodynamics, cardiac function, cardiomyocyte apoptosis, and expression of P53, Fas, Bax and Bcl-2 proteins in myocardium were determined in a rat model of acute myocardial infarction. Twenty-four male Sprague-Dawley rats weighing approximately 310 g were subjected to left coronary artery ligation. Seven days before surgery, the rats were randomized to receive cardiotrophin-1 (treated group) or phosphate-buffered saline (control group). Recombinant rat cardiotrophin-1 (2μg in 1 ml phosphate-buffered saline) or phosphate-buffered saline (1ml) was administered daily via the tail vein for 7 days (n=12 for each group). Hemodynamic parameters, apoptotic index, P53, Fas, Bax and Bcl-2 expression in myocardium were measured at 24 hours after coronary ligation. As compared with control animals, rats treated with cardiotrophin-1 had significantly higher mean arterial pressure, left ventricular systolic pressure and the maximum rate of left ventricular pressure rise or fall, and significantly lower left ventricular end-diastolic pressure. Cardiotrophin-1 pretreatment did not affect the heart rate, heart weight, body weight or the ratio of heart weight to body weight. The number of apoptotic cardiomyocytes in cardiotrophin-1 treated group was less than that in control group [(15.8±5.2) % vs (34.6±7.7) %, P<0.01]. Cardiotrophin-1 pretreatment significantly inhibited P53, Fas and Bax, and increased Bcl-2 expression in myocardium.
収録刊行物
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- The Journal of Medical Investigation
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The Journal of Medical Investigation 51 (1,2), 29-37, 2004
国立大学法人 徳島大学医学部
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詳細情報 詳細情報について
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- CRID
- 1390282679219862144
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- NII論文ID
- 110002239103
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- NII書誌ID
- AA11166929
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- ISSN
- 13496867
- 13431420
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- PubMed
- 15000253
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- 本文言語コード
- en
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- 資料種別
- journal article
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- データソース種別
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- JaLC
- IRDB
- Crossref
- PubMed
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