Concentration and Binding Capacity of Thyroxin-binding Prealbumin in Pregnancy, Hyper- and Hypothyroidism

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  • Sakurada Toshiro
    Department of Internal Medicine Tohoku University School of Medicine
  • Saito Shintaro
    Department of Internal Medicine Tohoku University School of Medicine
  • Inagaki Kiyoshi
    Department of Internal Medicine Tohoku University School of Medicine
  • Tayama Sumio
    Department of Internal Medicine Tohoku University School of Medicine
  • Torikai Tatsuo
    Department of Internal Medicine Tohoku University School of Medicine

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Thyroxin-binding capacity and concentration of TBPA (thyroxin-binding pre-albumin) were investigated with polyacrylamide gel electrophoresis in hyper- and hypothyroid patients before and after therapy, and in pregnant women before and after parturition. Binding capacity of TBG (thyroxin-binding globulin), free thy-roxin in plasma and other parameters of thyroid functions were also measured in these conditions.<br> Endogenous thyroxin decreased both the binding capacity and concentration of TBPA as did endogenous estrogen. In contrast, endogenous thyroxin decreased and endogenous estrogen increased the binding capacity of TBG.<br> Positive correlation was found between the binding capacity and concentra-tion of TBPA. Consequently, it was assumed that endogenous thyroxin decreased and estrogen increased the concentration of TBG.

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