Single Dose Administration of L-Carnitine Improves Antioxidant Activities in Healthy Subjects
-
- Cao Yu
- Department of Pharmacy, the Affiliated Hospital of Medical College, Qingdao University
-
- Qu Hai-jun
- Department of Pharmacy, the Affiliated Hospital of Medical College, Qingdao University
-
- Li Ping
- Department of Pharmacy, the Affiliated Hospital of Medical College, Qingdao University
-
- Wang Chun-bo
- Department of Pharmacology, Medical College, Qingdao University
-
- Wang Le-xin
- School of Biomedical Sciences, Charles Sturt University
-
- Han Zhi-wu
- Department of Pharmacy, the Affiliated Hospital of Medical College, Qingdao University
この論文をさがす
抄録
L-carnitine has been used as a supplement to treat cardiovascular or liver disease. However, there has been little information about the effect of L-carnitine on anti-oxidation capability in healthy human subjects. This study was designed to investigate the correlation between plasma L-carnitine concentration and antioxidant activity. Liquid L-carnitine (2.0 g) was administered orally as a single dose in 12 healthy subjects. Plasma concentration of L-carnitine was detected by HPLC. The baseline concentration of L-carnitine was 39.14 ± 5.65 μmol/L. After single oral administration, the maximum plasma concentration (Cmax) and area under the curve (AUC0-∞) were 84.7 ± 25.2 μmol/L and 2,676.4 ± 708.3 μmol/L·h, respectively. The half-life and the time required to reach the Cmax was 60.3 ± 15.0 min and 3.4 ± 0.46 h, respectively. There was a gradual increase in plasma concentrations of superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), catalase and total antioxidative capacity (T-AOC) in the first 3.5 h following L-carnitine administration. The plasma concentrations of SOD, GSH-Px, catalase and T-AOC returned to baseline levels within 24 h. A positive correlation was found between L-carnitine concentration and the antioxidant index of SOD (r = 0.992, P < 0.01), GSH-Px (r = 0.932, P < 0.01), catalase (r = 0.972, P < 0.01) or T-AOC (r = 0.934, P < 0.01). In conclusion, L-carnitine increases activities of antioxidant enzymes and the total antioxidant capacity in healthy subjects. It may be useful as a supplementary therapy for chronic illnesses involving excessive oxidative stress.
収録刊行物
-
- The Tohoku Journal of Experimental Medicine
-
The Tohoku Journal of Experimental Medicine 224 (3), 209-213, 2011
東北ジャーナル刊行会
- Tweet
詳細情報 詳細情報について
-
- CRID
- 1390282679220002304
-
- NII論文ID
- 10029051150
-
- NII書誌ID
- AA00863920
-
- ISSN
- 13493329
- 00408727
-
- 本文言語コード
- en
-
- データソース種別
-
- JaLC
- Crossref
- CiNii Articles
-
- 抄録ライセンスフラグ
- 使用不可