Crucial role of renin-angiotensin system in the pathogenesis of atherosclerosis

DOI 機関リポジトリ Web Site PubMed 被引用文献3件 参考文献137件 オープンアクセス
  • Sata Masataka
    Department of Cardiovascular Medicine, Institute of Health Bioscience, the University of Tokushima Graduate School
  • Fukuda Daiju
    Cardiovascular Division, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School

書誌事項

公開日
2010
資源種別
journal article
DOI
  • 10.2152/jmi.57.12
公開者
国立大学法人　徳島大学医学部

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説明

The renin-angiotensin system (RAS) has been demonstrated to play a critical role in the initiation and progression of atherosclerosis, thereby contributing to development of cardiovascular diseases. Angiotensin II (Ang II), a major substrate in RAS, stimulates atherosclerosis through various deleterious effects such as endothelial dysfunction, cellular proliferation and inflammation. Recently, local RAS in vasculature is reported to play an important role. Many of these atherogenic actions of Ang II are mediated by reactive oxygen species (ROS). Investigation of the role of ROS and inflammation induced by RAS may provide a clue to understanding the pathophysiology of atherosclerotic diseases, and may lead to a new therapeutic strategy. J. Med. Invest. 57: 12-25, February, 2010

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