Crucial role of renin-angiotensin system in the pathogenesis of atherosclerosis

DOI IR Web Site PubMed 3 Citations 137 References Open Access
  • Sata Masataka
    Department of Cardiovascular Medicine, Institute of Health Bioscience, the University of Tokushima Graduate School
  • Fukuda Daiju
    Cardiovascular Division, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School

Search this article

Description

The renin-angiotensin system (RAS) has been demonstrated to play a critical role in the initiation and progression of atherosclerosis, thereby contributing to development of cardiovascular diseases. Angiotensin II (Ang II), a major substrate in RAS, stimulates atherosclerosis through various deleterious effects such as endothelial dysfunction, cellular proliferation and inflammation. Recently, local RAS in vasculature is reported to play an important role. Many of these atherogenic actions of Ang II are mediated by reactive oxygen species (ROS). Investigation of the role of ROS and inflammation induced by RAS may provide a clue to understanding the pathophysiology of atherosclerotic diseases, and may lead to a new therapeutic strategy. J. Med. Invest. 57: 12-25, February, 2010

Journal

Citations (3)*help

See more

References(137)*help

See more

Keywords

Details 詳細情報について

Report a problem

Back to top