Crucial role of renin-angiotensin system in the pathogenesis of atherosclerosis

DOI 機関リポジトリ Web Site 被引用文献3件 参考文献137件
  • Sata Masataka
    Department of Cardiovascular Medicine, Institute of Health Bioscience, the University of Tokushima Graduate School
  • Fukuda Daiju
    Cardiovascular Division, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School

この論文をさがす

説明

The renin-angiotensin system (RAS) has been demonstrated to play a critical role in the initiation and progression of atherosclerosis, thereby contributing to development of cardiovascular diseases. Angiotensin II (Ang II), a major substrate in RAS, stimulates atherosclerosis through various deleterious effects such as endothelial dysfunction, cellular proliferation and inflammation. Recently, local RAS in vasculature is reported to play an important role. Many of these atherogenic actions of Ang II are mediated by reactive oxygen species (ROS). Investigation of the role of ROS and inflammation induced by RAS may provide a clue to understanding the pathophysiology of atherosclerotic diseases, and may lead to a new therapeutic strategy. J. Med. Invest. 57: 12-25, February, 2010

収録刊行物

被引用文献 (3)*注記

もっと見る

参考文献 (137)*注記

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ