Antihypertensive Effect of Spironolactone (SC-9420) on Experimental Renal Hypertension

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  • 福地 総逸
    Department of Internal Medicine, Tohoku University School of Medicine
  • 塩路 隆治
    Department of Internal Medicine, Tohoku University School of Medicine
  • 阿部 末三郎
    Department of Internal Medicine, Tohoku University School of Medicine

書誌事項

公開日
1962
資源種別
journal article
DOI
  • 10.1620/tjem.76.195
公開者
東北ジャーナル刊行会

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説明

Spironolactone was administered to rabbits with experimental renal hypertension. The blood pressure of these rabbits was decreased during spironolactone therapy. A marked increase in sodium and water excretion was noted on the third day, but potassium excretion did not change at that time. Treatment with spironolactone caused a rise of serum potassium in hypertensive rabbits. It is probable that spironolactone moves intracellular potassium out to extracellular space.<br> Assuming from these results, water and electrolyte metabolism is not normal in the experimental renal hypertension, probably accompanied with excessive mineralocorticoid secretion. But the abnormal water and electrolyte metabolism, and hyperaldosteronism in experimental renal hypertension seem to play an independent different role in the development and maintenance of arterial hypertension.<br> We are indebted to Prof. T. Torikai for his continuous leadership throughout this study.

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