Matrix Metalloproteinase-9 Is a Prognostic Marker to Predict Survival of Patients Who Underwent Surgery Due to Rectal Carcinoma
-
- Svagzdys Saulius
- Department of Surgery, Academy of Medicine, Lithuanian University of Health Science
-
- Lesauskaite Vaiva
- Institute of Cardiology, Academy of Medicine, Lithuanian University of Health Science
-
- Pangonyte Dalia
- Institute of Cardiology, Academy of Medicine, Lithuanian University of Health Science
-
- Saladzinskas Zilvinas
- Department of Surgery, Academy of Medicine, Lithuanian University of Health Science
-
- Tamelis Algimantas
- Department of Surgery, Academy of Medicine, Lithuanian University of Health Science
-
- Pavalkis Dainius
- Department of Surgery, Academy of Medicine, Lithuanian University of Health Science
この論文をさがす
説明
Common prognostic factors do not fully predict clinical outcomes in colorectal cancer, one of the most common malignancies in developed countries. Therefore, biological prognostic markers are under investigation. We investigated the prognostic value of expression of matrix metalloproteinases (MMP-2 and MMP-9) and their inhibitors (TIMP-2 and TIMP-3) in rectal carcinoma to predict survival of the patients. Retrospective analysis of clinicopathological findings of 64 patients who underwent rectal resection due to carcinoma and were followed-up from 2 to 96 months (median 48) was performed. Semi-quantitative scoring was used to assess the expression levels of MMP-2, MMP-9, TIMP-2 and TIMP-3 in rectal carcinoma. During the follow-up, 28 patients died. The deceased patients demonstrated significantly higher expression of MMP-9 and lower expression of TIMP-3 in parenchyma of carcinoma and lower expression of TIMP-2 in stroma of carcinoma, compared to survivors. Moreover, the deceased patients were associated with advanced tumor, metastases in lymph nodes and distant metastases. According to univariate analysis longer survival was predicted by lower expression of MMP-9 in parenchymal cells (p = 0.03), tumor size (early tumor) (p = 0.026), absence of metastases in lymph nodes (p = 0.02) or distant metastases (p = 0.04). Multivariate analysis revealed that metastases in lymph nodes, higher expression of MMP-9 in parenchyma, and lower expression of MMP-9 in stromal cells significantly increased mortality. Expression of MMP-9 in rectal carcinoma is a prognostic marker for overall survival. It is important to identify the origin of MMP-9 to predict better overall survival of the patients.
収録刊行物
-
- The Tohoku Journal of Experimental Medicine
-
The Tohoku Journal of Experimental Medicine 223 (1), 67-73, 2011
東北ジャーナル刊行会
- Tweet
キーワード
詳細情報 詳細情報について
-
- CRID
- 1390282679220759552
-
- NII論文ID
- 10027806699
-
- NII書誌ID
- AA00863920
-
- ISSN
- 13493329
- 00408727
-
- 本文言語コード
- en
-
- データソース種別
-
- JaLC
- Crossref
- CiNii Articles
-
- 抄録ライセンスフラグ
- 使用不可