Increased Mean Platelet Volume in Behçet's Disease with Thrombotic Tendency
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- Acikgoz Nusret
- Inonu University Faculty of Medicine, Department of Cardiology
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- Karincaoglu Yelda
- Inonu University Faculty of Medicine, Department of Dermatology
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- Ermis Necip
- Inonu University Faculty of Medicine, Department of Cardiology
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- Yagmur Jülide
- Inonu University Faculty of Medicine, Department of Cardiology
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- Atas Halil
- Inonu University Faculty of Medicine, Department of Cardiology
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- Kurtoglu Ertugrul
- Inonu University Faculty of Medicine, Department of Cardiology
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- Cansel Mehmet
- Inonu University Faculty of Medicine, Department of Cardiology
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- Barutcu Irfan
- Avicenna Hospital Department of Cardiology
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- Pekdemir Hasan
- Inonu University Faculty of Medicine, Department of Cardiology
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- Özdemir Ramazan
- Inonu University Faculty of Medicine, Department of Cardiology
書誌事項
- タイトル別名
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- Increased Mean Platelet Volume in Behçet's Disease with Thrombotic Tendency
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説明
The relationship between Behçet's disease (BD) and platelet aggregation has not sufficiently been investigated yet. Mean platelet volume (MPV) is a marker of platelet function, and the increase in MPV has been identified as an independent risk factor of recurrent vascular events. BD is characterized by a relapsing vasculitis of the venous as well as arterial thrombosis. However, the precise pathogenic mechanisms underlying thrombotic tendency in BD are not known. We hypothesized that there might be an association between thrombotic complication and MPV in these patients. Therefore, we investigated activation of platelets in patients with BD using a simple marker, MPV, the most accurate measure of platelet size. A total of 60 patients with BD and 40 age- and gender-matched controls were included. The BD patients were divided into subgroups based on the presence (n = 22) or absence of thrombosis (n = 38) and clinically active (n = 30) or inactive (n = 30) state. MPV was higher in patients with BD than controls (8.14 ± 0.8 vs. 7.48 ± 0.3 fl, p = 0.001). Among BD patients, MPV was larger in patients with thrombosis than those without thrombosis (8.45 ± 1.0 vs. 7.96 ± 0.7 fl, p = 0.038). However, there was no significant difference in MPV between BD patients with active and inactive states. The increase in MPV is independent of the disease activity, and the presence of thrombosis is associated with higher MPV in BD patients. Therefore, antiplatelet therapy may be useful to prevent thrombotic complications in BD patients.
収録刊行物
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- The Tohoku Journal of Experimental Medicine
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The Tohoku Journal of Experimental Medicine 221 (2), 119-123, 2010
東北ジャーナル刊行会
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詳細情報 詳細情報について
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- CRID
- 1390282679221011968
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- NII論文ID
- 10027084720
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- NII書誌ID
- AA00863920
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- ISSN
- 13493329
- 00408727
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- Crossref
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可