Acquired Resistance against the Growth of Yoshida Sarcoma Cells in Donryu Rats

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  • Sato Haruo
    Cancer Research Laboratory, the Research Institute for Tuberculosis, Leprosy and Cancer, Tohoku University
  • Satoh Hiroshi
    Medical Institute of Sasaki Foundation
  • Fujii Keiji
    Cancer Research Laboratory, the Research Institute for Tuberculosis, Leprosy and Cancer, Tohoku University

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The resistance phenomenon of the hosts against the tumor growth was investigated by using Yoshida sarcoma and Donryu rats. The animals were treated in various ways such as by giving heterograft (transplantation of mouse tumors), injection of cell suspension of various organs, injection of B. C. G., or administration of trypan-blue, typhoid-paratyphoid vaccine, zymosan or india ink, prior to transplantation of Yoshida sarcoma. The acquired resistance was clearly demonstrated especially when small number of tumor cells were inoculated.<br> Heterografting was the most effective to induce the resistance of the host against the tumor growth, while the resistance was moderately induced by injec-tion of B. C. G. or typhoid-paratyphoid vaccine.<br> Based on the data obtained, correlation between the resistance of the host against tumor growth and the role of the reticulo-endothelial system was discussed.

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