Comparison of Retinal Thickness Measurements Obtained by Four Optical Coherence Tomographers (OCTs)

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  • 4機器のOCTで評価した網膜厚の比較検討

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<p>[Purpose] Retinal thickness measurements by four optical coherence tomographers (OCTs) were compared, and measurement error and factors for the measurement error were investigated.</p><p>[Subjects and Methods] This study included 31 eyes of 31 healthy volunteers with no ocular diseases other than refractive error. Four OCTs, namely Spectralis OCT Compact, DRI OCT-1 Atlantis, RS-3000 Advance, and Cirrus HD-OCT, were used for measurement. Using the automated assessment protocols of the devices, central retinal thickness was measured three times in a row on the same day. The thickness measurements and coefficient of variance (CV) were compared among the four devices. </p><p>[Results] The subjects' mean age, refractive error, and axial length were 27.3 ± 6.9 years, -3.5 ± 3.2 D, and 24.7 ± 1.3 mm, respectively. The mean measurements of central retinal thickness by the four OCTs were 265.1 ± 21.6 μm (Spectralis OCT Compact), 234.0 ± 20.4 μm (DRI OCT-1 Atlantis), 261.8 ± 20.0 μm (RS-3000 Advance), and 250.7 ± 20.6 μm (Cirrus HD-OCT). DRI OCT-1 Atlantis obtained significantly smaller measurements than the other three devices (P < 0.01, ANOVA). The CV values were 0.005 ± 0.003 for Spectralis OCT Compact, 0.004 ± 0.003 for DRI OCT-1 Atlantis, 0.006 ± 0.005 for RS-3000 Advance, and 0.005 ± 0.003 for Cirrus HD-OCT. No significant difference was observed among the four devices. (P = 0.40, ANOVA) Using CV as the dependent variable and age, refractive error, and axial length as the independent variables, multivariable regression analysis showed that refractive error is an important determinant of CV with Cirrus HD-OCT (P < 0.01).</p><p>[Conclusion] The evaluation of central retinal thickness in normal eyes by the four OCTs revealed that DRI OCT-1 Atlantis obtained significantly smaller measurements than the other three OCTs. In addition, with Cirrus HD-OCT, refractive error was the most significant factor for CV.</p>

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