Spectrofluorometric Study on the Inclusion Reaction of Flavonols with .BETA.-Cyclodextrin.

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  • YAMADA Shinkichi
    Laboratory of Analytical Chemistry, Faculty of Engineering, Shizuoka University
  • SHIBATA Kazumi
    Laboratory of Analytical Chemistry, Faculty of Engineering, Shizuoka University
  • MURATA Akira
    Laboratory of Analytical Chemistry, Faculty of Engineering, Shizuoka University

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  • Spectrofluorometric Study on the Inclusion Reaction of Flavonols with β-Cyclodextrin

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Description

Kinetics and thermodynamics of the inclusion reaction of flavonols with β-cyclodextrin have been studied fluorometrically in 30%v/v methanolic aqueous solution. The equilibrium constants of this reaction were determined for flavonol and its 12 different hydroxy and methoxy derivatives in acidic and alkaline media where each flavonol is present quantitatively as fully protonated or deprotonated species. A thermodynamic consideration on the substituent effects reflected in these constants leads to a model for the present inclusion complex. With the inclusion constants for a monoprotic flavonol and its conjugate base, the effect of β-cyclodextrin on the acid dissociation equilibrium of the flavonol is quantitatively described. Kinetic aspects of this inclusion reaction are also discussed.

Journal

  • Analytical Sciences

    Analytical Sciences 9 (4), 467-471, 1993

    The Japan Society for Analytical Chemistry

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