First Functionalized MRI Contrast Agent Recognizing Vascular Lesions

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  • YAMAMOTO Tatsuhiro
    Department of Applied Chemistry, Faculty of Engineering, Kyushu University
  • IKUTA Kenjiro
    Department of Applied Chemistry, Faculty of Engineering, Kyushu University
  • OI Keiji
    Department of Cardiovascular Medicine, Kyushu University Graduate School of Medical Sciences
  • ABE Kohtaro
    Department of Cardiovascular Medicine, Kyushu University Graduate School of Medical Sciences
  • UWATOKU Toyokazu
    Department of Cardiovascular Medicine, Kyushu University Graduate School of Medical Sciences
  • MURATA Masaharu
    Department of Applied Chemistry, Faculty of Engineering, Kyushu University
  • SHIGETANI Noboru
    Department of Radiology, Kyushu University Hospital
  • YOSHIMITSU Kengo
    Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University
  • SHIMOKAWA Hiroaki
    Department of Cardiovascular Medicine, Kyushu University Graduate School of Medical Sciences
  • KATAYAMA Yoshiki
    Department of Applied Chemistry, Faculty of Engineering, Kyushu University

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Abstract

A new MRI-contrast agent, EB-DTPA-Gd, that has an Evans Blue analogue as a sensing unit for endothelium lesions, was designed and synthesized. The agent also has diethylenetriamine-N,N,N′,N″,N″-pentaacetic acid-Gd complex (Gadolinium-DTPA) units, which have been used as detection units for T1-weighted MRI. The EB-DTPA-Gd was able to recognize and adsorb to the vascular endothelium-denuded region of porcine aorta, and to decrease the relaxation time of circumferential water’s protons, making possible MR imaging of the endothelium-denuded region. The compound can be employed as a contrast agent for the imaging of vascular lesions using MRI.

Journal

  • Analytical Sciences

    Analytical Sciences 20 (1), 5-7, 2004

    The Japan Society for Analytical Chemistry

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