First Functionalized MRI Contrast Agent Recognizing Vascular Lesions
-
- YAMAMOTO Tatsuhiro
- Department of Applied Chemistry, Faculty of Engineering, Kyushu University
-
- IKUTA Kenjiro
- Department of Applied Chemistry, Faculty of Engineering, Kyushu University
-
- OI Keiji
- Department of Cardiovascular Medicine, Kyushu University Graduate School of Medical Sciences
-
- ABE Kohtaro
- Department of Cardiovascular Medicine, Kyushu University Graduate School of Medical Sciences
-
- UWATOKU Toyokazu
- Department of Cardiovascular Medicine, Kyushu University Graduate School of Medical Sciences
-
- MURATA Masaharu
- Department of Applied Chemistry, Faculty of Engineering, Kyushu University
-
- SHIGETANI Noboru
- Department of Radiology, Kyushu University Hospital
-
- YOSHIMITSU Kengo
- Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University
-
- SHIMOKAWA Hiroaki
- Department of Cardiovascular Medicine, Kyushu University Graduate School of Medical Sciences
-
- KATAYAMA Yoshiki
- Department of Applied Chemistry, Faculty of Engineering, Kyushu University
Search this article
Abstract
A new MRI-contrast agent, EB-DTPA-Gd, that has an Evans Blue analogue as a sensing unit for endothelium lesions, was designed and synthesized. The agent also has diethylenetriamine-N,N,N′,N″,N″-pentaacetic acid-Gd complex (Gadolinium-DTPA) units, which have been used as detection units for T1-weighted MRI. The EB-DTPA-Gd was able to recognize and adsorb to the vascular endothelium-denuded region of porcine aorta, and to decrease the relaxation time of circumferential water’s protons, making possible MR imaging of the endothelium-denuded region. The compound can be employed as a contrast agent for the imaging of vascular lesions using MRI.
Journal
-
- Analytical Sciences
-
Analytical Sciences 20 (1), 5-7, 2004
The Japan Society for Analytical Chemistry
- Tweet
Keywords
Details 詳細情報について
-
- CRID
- 1390282679232803328
-
- NII Article ID
- 130004440812
- 50000003296
-
- NII Book ID
- AA10500785
-
- COI
- 1:CAS:528:DC%2BD2cXmvFSqtA%3D%3D
-
- ISSN
- 13482246
- 09106340
-
- NDL BIB ID
- 6809971
-
- PubMed
- 14753250
-
- Web Site
- http://id.ndl.go.jp/bib/6809971
- https://ndlsearch.ndl.go.jp/books/R000000004-I6809971
- https://link.springer.com/content/pdf/10.2116/analsci.20.5.pdf
- https://link.springer.com/article/10.2116/analsci.20.5/fulltext.html
- http://www.jstage.jst.go.jp/article/analsci/20/1/20_1_5/_pdf
- https://search.jamas.or.jp/link/ui/2005098182
-
- Text Lang
- en
-
- Data Source
-
- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
-
- Abstract License Flag
- Disallowed