Continuous Measurement of Glutamate and Hydrogen Peroxide Using a Microfabricated Biosensor for Studying the Neurotoxicity of Tributyltin
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- KURITA Ryoji
- NTT Advanced Technology
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- HAYASHI Katsuyoshi
- NTT Microsystem Integration Laboratories
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- TORIMITSU Keiichi
- NTT Basic Research Laboratories
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- NIWA Osamu
- NTT Microsystem Integration Laboratories
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We first measured the effects of trace levels of an endocrine disruptor, tributyltin (TBT), on the secretion response from nerve cells using a microfabricated biosensor designed for the continuous measurement of L-glutamate and hydrogen peroxide. We observed higher and long-lasting glutamate and hydrogen peroxide concentrations from the cells when cultured rat cortical neurons were exposed to TBT. Glutamate and hydrogen peroxide release was induced even when we reduced the TBT concentration to 10 nM. This concentration is about two orders of magnitude lower than the concentration that induced apoptosis-like cell death. We also report on the effects of NMDA and non-NMDA receptor antagonists, which can help us to understand the mechanism of TBT neurotoxicity.
収録刊行物
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- Analytical Sciences
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Analytical Sciences 19 (12), 1581-1585, 2003
社団法人 日本分析化学会
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詳細情報 詳細情報について
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- CRID
- 1390282679232929280
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- NII論文ID
- 130004440674
- 10011873940
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- NII書誌ID
- AA10500785
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- COI
- 1:CAS:528:DC%2BD3sXpvV2nsbY%3D
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- ISSN
- 13482246
- 09106340
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- NDL書誌ID
- 6774620
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- PubMed
- 14696918
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可