Fluorescent Molecular Recognition for Endocrine-Disrupting Chemicals and Their Analogs by Fluorescent Hetero-Modified Cyclodextrins.

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  • NARITA Miyuki
    Department of Materials-process Engineering and Applied Chemistry for Environments, Faculty of Engineering and Resource Science, Akita University
  • OGAWA Nobuaki
    Department of Materials-process Engineering and Applied Chemistry for Environments, Faculty of Engineering and Resource Science, Akita University
  • HAMADA Fumio
    Department of Materials-process Engineering and Applied Chemistry for Environments, Faculty of Engineering and Resource Science, Akita University

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Abstract

Fluorescent molecular sensing for endocrine-disrupting chemicals and their analogs has been studied by investigating the fluorescence spectral change of regio-selective dansyl-tosyl-modified β- and γ-cyclodextrins upon the addition of a guest. These host compounds show pure monomer fluorescence at around 526 nm; the intensities of the guest-induced fluorescence either increase or decrease according to the accommodation of such guests as dioxin analogs, p-nonylphenol, 2,4-dichlorophenoxyacetic acid, bisphenol A, and diethylphthalate. The extent of the fluorescence variations with the guest is employed to display the sensing abilities of these hosts. The sensing parameter, ΔI/I 0 , was used to describe the sensing ability of the hosts, where I and I 0 are the fluorescence intensities in the presence and absence of a guest and ΔI=I-I 0. These hosts exhibit highly sensitive and selective molecular-recognition ability, particularly for 2,4,6-trichlorophenol and bisphenol A.

Journal

  • Analytical Sciences

    Analytical Sciences 16 (7), 701-705, 2000

    The Japan Society for Analytical Chemistry

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