Neutral-carrier-based ion-selective microelectrodes. Design and application. A review.

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  • BÜHRER Thomas
    Department of Organic Chemistry, Swiss Federal Institute of Technology (ETH)
  • GEHRIG Peter
    Department of Organic Chemistry, Swiss Federal Institute of Technology (ETH)
  • SIMON Wilhelm
    Department of Organic Chemistry, Swiss Federal Institute of Technology (ETH)

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  • Neutral-Carrier-Based Ion-Selective Microelectrodes Design and Application

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Description

At present, neutral-carrier-and ion-exchanger-based ion-selective liquid membrane microelectrodes are available for the measurement of H+, Li+, Na+, K+, Mg2+, Ca2+, NH4+ and Cl-. Fundamental aspects, design features and limitations of microelectrodes are discussed and examples for their application in physiology are given. The most important characteristics are summarized in view of intra-and extracellular physiological measurements. The selectivity coefficients KPotij with respect to the most common ions are compared to calculated values Kpotij, max required for measurements in intra-and extracellular samples without significant interference. For intracellular microelectrode studies, these required values are fully met for H+, K+, Mg2+, Ca2+ and Cl-, while in the case of extracellular measurements H+, Na+, K+ and Ca2+ can be assayed adequately.

Journal

  • Analytical Sciences

    Analytical Sciences 4 (6), 547-557, 1988

    The Japan Society for Analytical Chemistry

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