The Interaction of Copper-Bipyridyl Complex with DNA and Cleavage to DNA

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  • YANG Zhou-Sheng
    School of Chemistry and Materials Science, Anhui Normal University
  • WANG Yan-Ling
    School of Chemistry and Materials Science, Anhui Normal University
  • ZHAO Guang-Chao
    School of Chemistry and Materials Science, Anhui Normal University

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  • The Interaction of Copper-Dipyridyl Complex with DNA and Cleavage to DNA
  • Interaction of Copper Dipyridyl Complex with DNA and Cleavage to DNA

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Abstract

The interaction of a copper-bipyridyl (bpy) complex with CT-DNA was investigated by voltammetry, absorption and fluorescence spectrophotometry. The binding constant of the Cu(bpy)22+ complex interacting with DNA was 3.24 × 104 L/mol and the ability binding of Cu(bpy)22+ to DNA was 1.3-times as large as that of Cu(bpy)2+ to DNA. DNA could be efficiently cleaved by a potential-modulated method in the presence of the Cu(bpy)22+ complex. The fragments of the cleaved DNA were separated by high-performance liquid chromatography (HPLC). The experimental results revealed that the proposed method for DNA cleavage is highly efficient.

Journal

  • Analytical Sciences

    Analytical Sciences 20 (8), 1127-1130, 2004

    The Japan Society for Analytical Chemistry

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