Carbon Paste Electrode Based on Surface Activation for Trace Adriamycin Determination by a Preconcentration and Voltammetric Method.

DOI PDF Web Site Web Site Web Site ほか1件をすべて表示 一部だけ表示 参考文献28件

この論文をさがす

説明

A voltammetric determination of adriamycin (ADM) at a carbon paste electrode (CPE) in the presence of cetyltrimethylammonium bromide (CTAB) is described. ADM strongly adsorbs on the surface of the electrode by the adsorption of CTAB, thereby affecting the reduction current. This method provides a detection limit below 10-10 mol/L for ADM. The experimental parameters, which influence the voltammetric responses of ADM, e.g. the pH value, variety and concentration of surfactants and the scan rate, were optimized. The reduction peak current changes linearly with the ADM concentration over the range from 2.5 × 10-8 mol/L to 5 × 10-6 mol/L. The detection limit is 4 × 10-10 mol/L for an accumulation time of 3 min. The coefficient of variation, determined at 4 × 10-6 mol/L ADM, is 3.0% (n = 8). Using this method, ADM in the patient’s urine samples, which undergoes active ADM chemotherapy, was determined.

収録刊行物

  • Analytical Sciences

    Analytical Sciences 18 (10), 1089-1092, 2002

    社団法人 日本分析化学会

参考文献 (28)*注記

もっと見る

詳細情報 詳細情報について

問題の指摘

ページトップへ