M-DNA: A Self-Assembling Molecular Wire for Nanoelectronics and Biosensing.

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  • WETTIG Shawn D.
    Department of Biochemistry, University of Saskatchewan
  • LI Chen-Zhong
    Department of Biochemistry, University of Saskatchewan Department of Chemistry, University of Saskatchewan
  • LONG Yi-Tao
    Department of Biochemistry, University of Saskatchewan Department of Chemistry, University of Saskatchewan
  • KRAATZ Heinz-Bernhard
    Department of Biochemistry, University of Saskatchewan Department of Chemistry, University of Saskatchewan
  • LEE Jeremy S.
    Department of Biochemistry, University of Saskatchewan

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Abstract

M-DNA is a complex between divalent metal ions such as Zn2+ and duplex DNA which forms at pH 8.5. Unlike B-DNA, M-DNA does not bind ethidium so that M-DNA formation can be monitored conveniently by an ethidium fluorescence assay. M-DNA was shown to be a better conductor than B-DNA by fluorometric measurements of electron transport in donor-acceptor labelled duplexes; by direct conductivity measurements of M-DNA bound between gold electrodes and by cyclic voltammetric studies on ferrocene labelled duplexes attached to gold microelectrodes. As is the case with B-DNA, M-DNA can self-assemble into a variety of structures and is anticipated to find widespread use in nanoelectronics and biosensing.

Journal

  • Analytical Sciences

    Analytical Sciences 19 (1), 23-26, 2003

    The Japan Society for Analytical Chemistry

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