Chemiluminescence Determination of Tetracyclines Using a Tris(2,2'-bipyridine)ruthenium(II) and Potassium Permanganate System.
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- HAN Heyou
- Department of Chemistry, Wuhan University
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- HE Zhike
- Department of Chemistry, Wuhan University
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- ZENG Yun’e
- Department of Chemistry, Wuhan University
Bibliographic Information
- Other Title
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- Chemiluminescence Determination of Tetracyclines Using a Tris 2 2-bipyridine ruthenium 2 and Potassium Permanganate System
- Chemiluminescence Determination of Tetracyclines Using a Tris(2,2′-bipyridine)ruthenium(II) and Potassium Permanganate System
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Abstract
A chemiluminescence method for the determination of tetracyclines was developed. The method is based on an enhancement of tetracyclines upon the chemiluminescence light emission of tris(2,2′-bipyridine)ruthenium(II). In a sulfuric acid medium, chemiluminescence light emission is generated upon continuous oxidation of tris(2,2′-bipyridine)ruthenium(II) by potassium permanganate, catalyzed by Mn(II). The light-emission intensity is enhanced when the tetracyclines are also present in the reaction system. Under the optimum conditions, the calibration curves are linear over the range 1.0×10-7 - 1.0×10-5 g/ml for tetracycline, 4.0×10-8 - 1.0×10-5 g/ml for chlortetracycline and 1.0×10-7 - 1.0×10-5 g/ml for oxytetracycline. The limits of detection (S/N=3) are 2.0×10-8 g/ml for tetracycline, 1.0×10-8 g/ml for chlortetracycline and 2.0×10-8 g/ml for oxytetracycline. The proposed method was used to determine tetracyclines in pharmaceutical formulations with good results.
Journal
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- Analytical Sciences
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Analytical Sciences 15 (5), 467-470, 1999
The Japan Society for Analytical Chemistry
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Details 詳細情報について
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- CRID
- 1390282679235027456
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- NII Article ID
- 130004440067
- 10002419772
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- NII Book ID
- AA10500785
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- COI
- 1:CAS:528:DyaK1MXjtFeqtb4%3D
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- ISSN
- 13482246
- 09106340
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- NDL BIB ID
- 4721841
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
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- CiNii Articles
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- Abstract License Flag
- Disallowed