Inclusion Reaction of Some Fluorophores with β-Cyclodextrin and Its Effect on Their Reversed-Phase HPLC Retention

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  • YAMADA Shinkichi
    Laboratory of Analytical Chemistry, Faculty of Engineering, Shizuoka University
  • MURABAYASHI Katsunori
    Laboratory of Analytical Chemistry, Faculty of Engineering, Shizuoka University
  • NAKAMURA Motoshi
    Laboratory of Analytical Chemistry, Faculty of Engineering, Shizuoka University

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タイトル別名
  • Inclusion Reaction of Some Fluorophores with .BETA.-Cyclodextrin and Its Effect on Their Reversed-Phase HPLC Retention.
  • Inclusion Reaction of Some Fluorophores

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The thermodynamics of the inclusion reaction of flavonol, 7-methoxyflavonol and 4-phenyl-7-hydroxycoumarin (L) with β-cyclodextrin (CD) has been studied fluorometrically with special reference to the effect of organic solvents (S). The equilibrium constants for this reaction were determined in aqueous methanol, ethanol, acetonitrile, acetone, dimethyl sulfoxide, and N,N-dimethylformamide. The dependence of the constants on the content of the respective S was attributable to the substitution of S included in CD with L as CD·nS+L⇔CD·L+nS. Also, the inclusion constants of S with CD, βn=[CD·nS][CD]-1[S]-n, were found to be linearly correlated with the solubility parameter of S for both n=1 and 2. When aqueous methanol was employed as a mobile phase, the retention behavior of coumarins on a reversed-phase HPLC column was studied in the presence of β-CD as a mobile-phase component. The change in the capacity factors could be reasonably explained by the same inclusion scheme as that mentioned above.

収録刊行物

  • Analytical Sciences

    Analytical Sciences 14 (5), 897-901, 1998

    社団法人 日本分析化学会

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