Zinc Nanoparticles-equipped Bioelectronic Nose Using a Microelectrode Array for Odorant Detection
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- ZHANG Qian
- Biosensor National Special Laboratory, Department of Biomedical Engineering, Zhejiang University Cyber Innovation Joint Research Center, Zhejiang University
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- ZHANG Diming
- Biosensor National Special Laboratory, Department of Biomedical Engineering, Zhejiang University Cyber Innovation Joint Research Center, Zhejiang University
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- LI Nantao
- Biosensor National Special Laboratory, Department of Biomedical Engineering, Zhejiang University Cyber Innovation Joint Research Center, Zhejiang University
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- LU Yanli
- Biosensor National Special Laboratory, Department of Biomedical Engineering, Zhejiang University Cyber Innovation Joint Research Center, Zhejiang University
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- YAO Yao
- Biosensor National Special Laboratory, Department of Biomedical Engineering, Zhejiang University Cyber Innovation Joint Research Center, Zhejiang University
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- LI Shuang
- Biosensor National Special Laboratory, Department of Biomedical Engineering, Zhejiang University Cyber Innovation Joint Research Center, Zhejiang University
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- LIU Qingjun
- Biosensor National Special Laboratory, Department of Biomedical Engineering, Zhejiang University Cyber Innovation Joint Research Center, Zhejiang University
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Abstract
Bioelectronic noses, such as olfactory cell- and receptor-based biosensors, have important applications for biomimetic odorant detection in various fields. Here, a nanoparticle-equipped biosensor was designed to record extracellular potentials from olfactory receptor cells effectively. In this research, a microelectrode array (MEA) was combined with olfactory epitheliums as the olfactory biosensor to record electrophysiological signals of receptor cells in the epitheliums. Zinc nanoparticles (NanoZn) were employed along with the biosensor for different kinds of odorant measurements, which improved the electrophysiological responses to odor molecules. The NanoZn-equipped biosensor showed greater performance, such as a higher sensitivity and a larger signal-to-noise ratio, than that without the nanoparticles. Thus, this approach provided a promising method to improve the detecting performance of biosensors based on olfactory cells and receptors, which would bring broad application prospects for bioelectronic noses in environmental monitoring, food analysis, and healthcare diagnosis.
Journal
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- Analytical Sciences
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Analytical Sciences 32 (4), 387-393, 2016
The Japan Society for Analytical Chemistry
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Details 詳細情報について
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- CRID
- 1390282679235582080
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- NII Article ID
- 130005143824
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- NII Book ID
- AA10500785
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- ISSN
- 13482246
- 09106340
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- NDL BIB ID
- 027244996
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- PubMed
- 27063709
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- Web Site
- http://id.ndl.go.jp/bib/027244996
- https://ndlsearch.ndl.go.jp/books/R000000004-I027244996
- https://link.springer.com/content/pdf/10.2116/analsci.32.387.pdf
- https://link.springer.com/article/10.2116/analsci.32.387/fulltext.html
- https://www.jstage.jst.go.jp/article/analsci/32/4/32_387/_pdf
- https://search.jamas.or.jp/link/ui/2016362842
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed