An Adult Case of Virus Associated Hemophagocytic Syndrome Which Developed from Infectious Mononucleosis.

DOI 2 Citations 25 References

Bibliographic Information

Other Title
  • ウィルス関連血球貧食症候群例　　伝染性単核球症に続発した成人例
  • ―伝染性単核球症に続発した成人例―

Search this article

Description

An adult case of virus associated hemophagocytic syndrome (VAHS) which developed from infectious mononucleosis (IM) is reported. A 21-year-old-man visited our clinic with complaints of high fever, sore throat, and cervical lymphadenopathy. The palatine tonsils appeared to be swollen with white plugs on the surface. Hematological examination revealed mononucleosis with atypical lymphocytes in the peripheral blood. The serum LDH level was elevated. Serum antibodies to Epstein-Barr virus (EBV) showed a primary infection pattern. The patient, on the basis of these findings, was initially diagnosed with IM. The symptoms and laboratory data subsequently showed transient improvement; however, liver dysfunction, pancytopenia, and interstitial pneumonia ultimately developed. Bone marrow puncture was performed 29 days after admission and revealed inflitration of a number of mature histiocytes with erythrophagia, suggesting that VAHS had developed from IM. Combined chemotherapy with prednisolone, interferon, acyclovir, and VP-16, was not effective, and progressive liver dysfunction and pancytopenia advanced. He died 47 days later of disseminated intravascular coagulopathy.

Journal

Citations (2)*help

See more

References(25)*help

See more

Keywords

Details 詳細情報について

Report a problem

Back to top